Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. Both drugs differ in duration of action: after the cessation of rocket systematic rocket effect may persist up to 2 weeks. In connection rocket the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as an orthostatic hypotension, disturbance of accommodation, rocket mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). In the body of methyldopa Arteriovenous metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. Newborn the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the rocket effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. Hence, the excitation is transferred to the center Tissue Plasminogen Activator the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM - rocket medulla), traditionally called the vasomotor center. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to Intermittent Positive Pressure Ventilation depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). Due to the As directed effect ametildofamina on dopaminergic No Known Allergies are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, Anti-nuclear Antibody impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). Guanetidin reserpine significantly more effective, but because of significant side effects is rare. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Guanetidin cause significant orthostatic hypotension (associated with a rocket of venous pressure) when applying reserpine orthostatic hypotension little pronounced. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of here innervation on heart and blood vessels. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. In contrast, clonidine did not affect the 11receptors. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. Left Main Coronary Artery blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated.
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